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The pathogens can be sprayed in many ways, via natural or forced ventilation system, water spray, skin scales released by patients and medical staff, coughing and sneezing . Studies also show that staff members can liberate between 1,500 to 50,000 bacteria per minute and those pathogens suspension in the air for long periods that 80 to 90% of all surgical wound bad air quality and that cleaner infection risk. Studies on hospital acquired infections began more than 150 years ago with Ignaz Semmel